NACARI
Research type
Research Study
Full title
The NAtional CArdioRenal research Initiative (NACARI)
IRAS ID
300944
Contact name
Dorothea Nitsch
Contact email
Sponsor organisation
LSHTM: Research Governance & Integrity Office
Duration of Study in the UK
2 years, 4 months, 30 days
Research summary
Although ischaemic heart disease is a leading causes of death worldwide, improvements in treatments has resulted in substantially increased rates of survival. With population ageing and increasing rates of overweight, obesity, and diabetes, there are more and more people who have chronic kidney disease. As a result, a larger population of patients now live with both conditions. Yet, there are very limited data concerning the interplay between these two conditions, as well as approaches to their management. Cardiac death is common for people with kidney disease, but most cardiac trials exclude patients with significant kidney disease. It is therefore essential to generate longitudinal population cohort studies to improve our understanding of cardiac and kidney care. As well as refining current treatment, this will enable the identification of higher risk groups for clinical intervention (including the development of clinical trials and registry based trials) to avoid, treat, or prevent adverse interactions between cardiovascular treatments and kidney disease states.
We are a national research collaboration called NACARI (the NAtional CArdiorenal Research Initiative) which started as a project on improving cardiac care for patients with kidney disease (funded by the Health Foundation). We are establishing a national linked data resource containing information from patients with both heart and kidney disease so we can understand better how people with these common conditions are managed. Importantly we will be using only data from which patient identities have been removed.
REC name
Yorkshire & The Humber - Leeds East Research Ethics Committee
REC reference
21/YH/0270
Date of REC Opinion
25 Oct 2021
REC opinion
Favourable Opinion