Myocardial Perfusion Assessment With Intravascular Contrast Agents

• Research type

  Research Study

• Full title

  Quantitative Assessment of Myocardial Perfusion with Magnetic Resonance Using an Intravascular Contrast Agent

• Sponsor organisation

  King's College London

• Eudract number

  2008-004895-39

• ISRCTN Number

  No number provided

• Clinicaltrials.gov Identifier

  No number provided

• Research summary

  Coronary heart disease (CHD) is the most common cause of illness and death in the UK. A reduction in the blood flow to the heart muscle ("myocardial perfusion") is the first detectable abnormality. Current tests to measure myocardial blood flow are limited by relatively poor image quality and/or exposure to ionising radiation (X rays). Cardiac magnetic resonance imaging (CMR) offers better image detail and does not expose patients to harmful radiation.Recently, new CMR methods for the true-quantitative measurement of blood flow to the heart have been developed. These new techniques could provide a reliable method to evaluate patients with suspected or known CHD, providing new functional information that are difficult to gather at the moment using different methods.These new techniques may have a role in the diagnosis in patients with more than one diseased vessel and in studies aimed towards the demonstration of the beneficial effects of therapeutic interventions.In this study we will undertake a true-quantitative measurement of myocardial blood flow in patients with known CHD. For this purpose we will optimize the parameters, the type of contrast agent and the administration scheme needed to acquire the images and will administrate adenosine to induce detectable changes in myocardial blood flow.

• REC name

  London - London Bridge Research Ethics Committee

• REC reference

  08/H0804/95

• Date of REC Opinion

  26 Feb 2009

• REC opinion

  Further Information Favourable Opinion