Muscle repair during the menopause
Research type
Research Study
Full title
The importance of oestrogen in the muscle repair process: Implications for the menopause
IRAS ID
339521
Contact name
Sophie Joanisse
Contact email
Sponsor organisation
University of Nottingham
Duration of Study in the UK
2 years, 0 months, 1 days
Research summary
Regulation of a unique muscle-specific stem cell population commonly referred to as satellite cells (MuSC) plays a vital role in the growth and remodelling of skeletal muscle tissue. Importantly, these cells and are necessary for muscle repair. The MuSC response following exercise induced muscle damage (EIMD) has been a topic of intense research, however the majority of this work is in males. Work in rodents has described an important role for oestrogen in the regulation of MuSC and, in humans MuSC express the oestrogen receptor. Our current knowledge surrounding the role of oestrogen signalling in the muscle repair process following EIMD, specifically the regulation of MuSC in humans is limited. Menopause is a naturally occurring process that occurs in all women and is characterized by sudden oestrogen deficiency and is an ideal model to study the role of oestrogen in skeletal muscle. Therefore, we will study the MuSC response to EIMD, a model previously shown to activate MuSC, in pre-menopausal and post-menopausal similar in age. Blood and muscle samples will be collected in all women before and 24- and 72 hours after completing a bout of 300 maximal eccentric contractions of the leg.
REC name
Yorkshire & The Humber - Bradford Leeds Research Ethics Committee
REC reference
24/YH/0070
Date of REC Opinion
21 Mar 2024
REC opinion
Favourable Opinion