Multiple Pregnancy Registry
Research type
Research Database
IRAS ID
178088
Contact name
Asma Khalil
Contact email
Research summary
Multiple Pregnancy Registry
REC name
Wales REC 5
REC reference
15/WA/0145
Date of REC Opinion
22 May 2015
REC opinion
Further Information Favourable Opinion
Data collection arrangements
Routinely recorded anonymised data related to mutiple pregnancy will be stored on a secured website database (Registry). The inclusion criteria include complicated multiple pregnancies (twin-to-twin transfusion syndrome, selective fetal growth restriction, twin anaemia polycythaemia sequence, twin reversed arterial perfusion, twin discordant anomaly, single intrauterine demise), triplet pregnancies, and uncomplicated Monochorionic twin pregnancies. The exclusion criteria include uncomplicated dichorionic twin pregnancies
The data will be collected by the local team in each centre contributing to the Registry. The team members performing this task will hold a valid good clinical practice (GCP) certificate, to ensure their awareness of clinical governance and the Data Protection Act.
Research programme
This is a UK national initiative endorsed by the Royal College of Obstetricians and Gynaecologists (RCOG), British Maternal Fetal Medicine Society (BMFMS) and the Twin and Multiple Births Association (TAMBA). The aims include: • Systematically tracking complicated multiple pregnancies, triplet and uncomplicated monochorionic twin pregnancies to ascertain pregnancy outcomes and address the gaps in knowledge • Improving patient care in clinical practice • Contributing data to quality benchmarking projects, audits and research studies • Facilitating an easier option to meet near future reporting requirements and performance expectations • Establish a platform to allow long-term follow-up of these infants at a national level. The Registry would allow the possibility of following up a large cohort of twins whose pregnancies were complicated, whether they had treatment or not. These long-term data cannot be determined from short-term clinical trials in selected patients. Some of the neurodevelopmental outcomes cannot be assessed in a robust manner during infancy or early childhood, and most of the studies reporting on the neurodevelopmental outcomes have not followed-up these children beyond the age of two years.
Research database title
Multiple Pregnancy Registry
Establishment organisation
St George's Healthcare NHS Trust
Establishment organisation address
Blackshaw Road
SW17 0QT