Multiple myeloma lifestyle study
Research type
Research Study
Full title
Lifestyle study of patients with Multiple Myeloma
IRAS ID
128399
Contact name
Kwee Yong
Contact email
Sponsor organisation
University College London Joint Research Office
Research summary
The aim of this study is to evaluate the practicality and feasibility of carrying out an exercise training programme in patients with myeloma (a cancer of the bone marrow), and to determine the benefits of such a programme. The primary objective is to test the hypothesis that the programme will improve fatigue by clinically significant levels after 3 months of the exercise programme, when compared with usual care. This controlled randomised trial is embedded in a cohort study of lifestyle and physical health in myeloma survivors who are in remission (stable phase of disease). We will recruit 100 participants into the cohort study, from the myeloma clinics at UCLH. Following assessment and screening, patients who fulfil eligibility criteria for the exercise programme will be randomised to either the intervention group or ‘remain in cohort’ group (i.e. the control group), but only those in the intervention group will be informed of this. Those selected for the intervention group will be asked if they would like to take part in an individually-tailored exercise programme. Consenting participants will be asked to exercise 3 times a week for 6 months; during the first 3 months one of these weekly sessions will be supervised by specialist Physiotherapists at UCLH. All other sessions will take place at home.
All participants will be assessed at the same study time points (baseline, 3, 6 and 12 months from study entry). Outcome measures include clinical assessments, questionnaires, monitoring of physical activity using motion sensor and physiological assessments (physical fitness, muscle strength, bone health, immune function and physical ability).
We believe that exercise, in the form of a individually tailored training programme, will increase the general fitness, muscle strength and energy levels of patients with myeloma and also lead to improvements in mood and self-confidence.
REC name
London - Queen Square Research Ethics Committee
REC reference
13/LO/1105
Date of REC Opinion
10 Jan 2014
REC opinion
Further Information Favourable Opinion