Multimodality Monitoring Directed Management of Traumatic Brain Injury
Research type
Research Study
Full title
Multimodality Monitoring Directed Management of Traumatic Brain Injury
IRAS ID
214040
Contact name
Adel Helmy
Contact email
Sponsor organisation
Cambridge University Hospitals NHS Foundation Trust and the University of Cambridge
Clinicaltrials.gov Identifier
Duration of Study in the UK
4 years, 11 months, 29 days
Research summary
Head injury (Traumatic Brain Injury, TBI) is a common cause of death and disability. Our current treatments focus on preventing further (secondary) injury by monitoring the pressure inside the head (intracranial pressure, ICP) and treating it. Many other monitors, including brain tissue oxygen and metabolism (how the brain generates energy), have been proven to reflect secondary injury to the brain and they are used routinely in all head injury patients in Neurointensive Care. Despite the wide use of these monitors, there is no accepted protocol to determine which treatment is most appropriate in each situation when the information from all the monitors is combined. An international consensus meeting in 2014 identified this as a key research question that would allow us to use the monitoring in a more structured way that can improve outcomes from head injury. We have designed a study protocol that combines the information from all the monitors (so called multi-modality monitoring), based on the research data from the consensus meeting, and allows us to pick treatments in a rational and consistent way. After each treatment is used (e.g. raising blood pressure, increasing oxygen through a ventilator) we can use the multi-modality monitoring to prove that we are improving the environment for the injured brain. In addition, we would like to explain why some patients respond to specific treatments. We will do this by collecting detailed data on each patient as well as any biological samples that are already available in intensive care.
REC name
London - Queen Square Research Ethics Committee
REC reference
17/LO/0587
Date of REC Opinion
16 May 2017
REC opinion
Further Information Favourable Opinion