MRI study of nerve inflammation in whiplash
Research type
Research Study
Full title
Magnetic resonance imaging study to investigate possible nerve inflammation in patients with chronic whiplash associated disorder
IRAS ID
133993
Contact name
Andrew Dilley
Contact email
Sponsor organisation
Brighton and Sussex Medical School
Research summary
Arm and neck pain can occur following whiplash injury to the neck and commonly occurs as the result of an automobile accident. In many cases, symptoms resolve within a few weeks. However, there appears to be a growing pandemic of chronic neck and arm pain post injury where symptoms do not resolve. Current treatments for such patients appear ineffective, largely due to a lack of understanding of this condition.
Patients with chronic whiplash associated disorder (WAD) frequently describe painful symptoms that are often associated with nerve injury. On clinical examination, these patients do not show evidence of an obvious nerve injury. However, there are subtle changes in the function of the nerves in the shoulder and arm. There is also the suggestion that these nerves become sensitive to small stretches during limb movements and pressure. Work from our laboratory has suggested that nerve inflammation may be a cause of such painful symptoms. Using magnetic resonance imaging (MRI), we have identified nerve inflammation as being a possible source of symptoms in patients with other chronic musculoskeletal disorders where patients present without clear clinical signs of nerve injury.
In this study, we will use MRI to look for nerve inflammation in patients with WAD. Images from these patients will be compared to healthy individuals. To further characterise these patients, we will also perform a clinical examination of the upper limb to identify areas of symptoms, ranges of joint movement and look for signs of nerve tenderness. Participants will complete the Neck Disability Index questionnaire and Leeds Assessment of Neuropathic Symptoms and Signs questionnaire, which will be used to obtain information on symptom severity.
If nerve inflammation can be ‘measured’ in patients with chronic whiplash, then this study would provide new objective evidence for the cause of arm symptoms in this patient group
REC name
London - Brighton & Sussex Research Ethics Committee
REC reference
13/LO/1178
Date of REC Opinion
20 Sep 2013
REC opinion
Favourable Opinion