MRI in preoperative radiotherapy for soft tissue sarcoma (MISTS)

• Research type

  Research Study

• Full title

  Phase I feasibility study to compare early response assessment and planning volumes with contrast-enhanced computed tomography (CT), MRI including diffusion weighted MRI (DWI) and dynamic-contrast enhanced (DCE) MRI in patients with limb sarcoma undergoing pre-operative radiotherapy.

• IRAS ID

  129229

• Contact name

  Prakash Manoharan

• Contact email

  prakash.manoharan@christie.nhs.uk

• Sponsor organisation

  The Christie NHS Foundation Trust

• Research summary

  This study will use specialised MRI techniques to detect changes in blood flow and in tumour cells within the sarcoma. These changes may reflect the sensitivity of the tumour to radiotherapy and may be associated with long term outcome after treatment.
  We plan to recruit 15 patients who would be having pre-operative radiotherapy as part of their sarcoma treatment. Within our study, these patients would have an additional three specialised MRI scans: one prior to the start of radiotherapy, one during the second week of radiotherapy while on treatment and one scan the week before the operation after the completion of radiotherpy.
  After the operation, the sarcoma will be processed as usual by the sarcoma pathologist and the changes within the sarcoma tissue will be compared to the findings of the scans and outcome after treatment.
  The main aim of this study is to see if it is feasible for patients to have all three specialised MRIs and to see if there are any radiological factors which might be worth further investigation in a large phase III study

• REC name

  North West - Greater Manchester East Research Ethics Committee

• REC reference

  13/NW/0500

• Date of REC Opinion

  22 Jul 2013

• REC opinion

  Favourable Opinion