MRI for lung radiotherapy; a prospective study.
Research type
Research Study
Full title
MRI for lung radiotherapy; a prospective study.
IRAS ID
237097
Contact name
Michael Brada
Contact email
Sponsor organisation
The Clatterbridge Cancer Centre NHS Foundation Trust
Duration of Study in the UK
0 years, 6 months, 0 days
Research summary
The purpose of this study is to investigate the use of Magnetic Resonance Imaging (MRI) in the diagnostic and planning phase of radiotherapy for lung cancer and then introduce it into on-treatment imaging to improve the accuracy of radiotherapy. The study compromises of two phases, a technical phase followed by a clinical phase.
The aim of the technical phase is to develop and test MR sequences using a diagnostic scanner for use in the chest. This will be carried out on a humanoid phantom and subsequently healthy volunteers.
The second phase will be a clinical phase to assess the accuracy of visualising all thoracic structures and the tumour in lung cancer patients using the defined MR sequences. It will compromise of 2 parts; the first part will involve 3 lung cancer patients as a pilot to enable the fine tuning of the sequences. The 2nd part will involve the evaluation of MRI in relation to planning CT in 12 lung cancer patients.
The hypothesis is that the use of 4D MRI will be more accurate in defining the tumour and intrathoracic structures than achieved with the current standard of 4DCT to improve the accuracy and potentially the outcome of radical radiotherapy for non-small cell lung cancer.
REC name
North West - Liverpool Central Research Ethics Committee
REC reference
18/NW/0078
Date of REC Opinion
14 May 2018
REC opinion
Further Information Favourable Opinion