MRI application for additional imaging
Research type
Research Study
Full title
Creation of well characterised cohorts of patients referred for clinical Magnetic Resonance Imaging for better understanding of cardiovascular conditions
IRAS ID
172376
Contact name
Reza Razavi
Contact email
Sponsor organisation
King’s College London
Duration of Study in the UK
10 years, 0 months, 4 days
Research summary
We run an integrated clinical and research program in cardiovascular Magnetic resonance imaging (MRI) at King’s College London and Guys and St Thomas’ NHS foundation Trust.
This application updates the ethics and R+D approval for one of our ongoing studies (reference REC 09/H0802/078). There are three elements to this application, the most fundamental is covered on our existing approval. This is fifteen minutes for additional MRI scans to improve their clinical value and advance research. In addition to further our understanding of cardiovascular disease, in this application we are applying to access patients’ notes, recall patients and collect blood samples. This will enable us to build cohorts (a bioresource) of patients who have had detailed assessment of their cardiovascular system by MRI.
MRI uses magnetic fields and radio−frequency (RF) waves to produce images of the internal structure of the human body. A clinical examination consists of a number of sequences of magnetic and RF pulses with each sequence producing an image or set of images. The information contained in these images depends to a large extent on the choices made when designing the imaging sequence. There are a large number of different parameters that may be changed to improve the clinical usefulness of the images. While it may be useful in some cases to perform a dedicated clinical trial of a proposed new MRI technique, in many cases it is adequate to trial changes to existing sequences on small numbers of patients. In this way research can advance quickly and beneficial changes can be made to clinical scan protocols in a timely fashion.
REC name
North of Scotland Research Ethics Committee 1
REC reference
15/NS/0030
Date of REC Opinion
1 Apr 2015
REC opinion
Favourable Opinion