MRI-AIDED Study v1.0 [COVID-19]
Research type
Research Study
Full title
Long-term outcomes after Acute Kidney Injury in Coronavirus disease (COVID-19) as determined by multiparametric magnetic resonance imaging (MRI)
IRAS ID
287571
Contact name
Maarten W Taal
Contact email
Sponsor organisation
University Hospitals of Derby & Burton NHS Foundation Trust
Clinicaltrials.gov Identifier
N/A, N/A
Duration of Study in the UK
2 years, 11 months, 31 days
Research summary
The purpose of the present study is to investigate the effects of acute kidney injury (AKI; a sudden reduction in kidney function) in people who have been treated in hospital for COVID-19. We would like to study whether peoples’ kidneys recover completely or whether there are any signs of long term kidney damage, and we wish to do so using detailed magnetic resonance imaging (MRI) scans of the kidney (this is called multiparametric MRI). We will also scan other organs in the abdomen (liver and spleen) to assess if there are effects of COVID-19 on these. Finally, we will perform a limited MRI scan of the heart to assess heart function and how this may affect kidney function. We have seen that many people who have had more severe forms of COVID-19 have also had AKI. It is important to understand the effects of AKI so we can decide how best to monitor and treat patients in this situation.\n\nThe study will recruit patients who had COVID-19, were admitted to hospital, required intensive care, and/or developed AKI during their hospital stay. We will collect information from their medical records about their hospital admission with COVID-19. During the first study visit (3-6 months after hospital discharge), participants will have their weight, height and blood pressure measured and complete a questionnaire. We will also take blood and urine samples, measure the accumulation of toxins in their skin using a safe, quick and painless technique called skin autofluorescence, and conduct an MRI scan of their kidneys, abdomen and heart. \n\nAfter this visit, we will ask participants to come back for two more study visits, which will be arranged at 12 and 24 months after their hospital discharge. These visits will consist of the same procedures and measurements done in their first study visit.
REC name
North West - Greater Manchester South Research Ethics Committee
REC reference
20/NW/0357
Date of REC Opinion
8 Sep 2020
REC opinion
Further Information Favourable Opinion