MRAHF Study
Research type
Research Study
Full title
Incidence of significant mitral regurgitation in patients presenting with acute heart failure. Journey to Tertiary Centre.
IRAS ID
194815
Contact name
Aigul Baltabaeva
Contact email
Sponsor organisation
Metanoic Health Ltd.
Clinicaltrials.gov Identifier
Clinicaltrials.gov Identifier
CRN Ref, 5625
Duration of Study in the UK
1 years, 7 months, 17 days
Research summary
This is a trial to study the incidence of significant MR (grade 3 and above) in patients presenting acutely to district general hospital with symptoms of breathlessness and palpitations requiring hospital admission.\n\nThe previous history of hospital admissions with HF will be collected retrospectively to calculate the economic impact of severe MR. Separate analysis will be carried out retrospectively to study the rate of referral to tertiary centre for correction of MR based on database of Harefield Hospital as well as prevalence of MR in patients with known HF managed by Specialist HF nurses in the community.\n\nAll patients admitted with symptoms of HF- (shortness of breath (SOB), peripheral oedema, palpitations and irregular heart beats) will be assessed by our Research Team. The level of BNP will be checked using a small device (i-STAT BNP) at the bedside. If results of the test suggest HF they will undergo special procedure called transthoracic echocardiography (TTE). TTE is an ultrasound scan of the heart which will enable us to find if there is a leakiness to the heart valves as well as strength of the heart muscle. We will use bi-plane Simpton’s method to calculate left ventricular (LV) ejection fraction (EF). Colour Doppler and PISA method will be used to quantify severity of valve leak. Simultaneously there will be recording of heart sounds to find out if auscultation is reliable in identifying leaky valves.
REC name
North of Scotland Research Ethics Committee 2
REC reference
16/NS/0047
Date of REC Opinion
28 Apr 2016
REC opinion
Favourable Opinion