MR Fingerprinting Brain Tumours - a pilot study
Research type
Research Study
Full title
MR Fingerprinting Brain Tumours – a pilot study
IRAS ID
252664
Contact name
Matthew Grech-Sollars
Contact email
Sponsor organisation
Imperial College London
Duration of Study in the UK
6 years, 11 months, 31 days
Research summary
Magnetic Resonance Fingerprinting (MRF) is a novel rapid imaging technique which aims to assess physical properties of different tissue using one short MRI sequence. Using innovative techniques, MRF is able to extract quantitative values. It determines these quantitative features through the unique signal evolutions that different tissue types show. It is expected that MRF will distinguish between tissue with different biological components, such as heterogenous brain tumour tissue. Much the same way as fingerprints can be used to determine the identity of a person, MRF uses a dictionary to associate each of the unique signal evolutions acquired with a specific tissue type. Due to the novelty of the method limited literature on MRF in brain tumours exists and further sequence development is required to optimise the imaging in this patient cohort. The benefits of MRF are promising both in terms of reducing the scanning time in the clinic (approx. 5 minutes), and its ability to provide a quantitative and reproducible imaging biomarker. In this study we will develop MRF at Imperial College on a phantom, a set of healthy volunteers and then test this out in an initial group of patients with brain tumours. 10 healthy volunteers and 20 patients with glioma will be recruited to this prospective study. They will have one MRI scan take place at Hammersmith Hospital pre-treatment.
REC name
West Midlands - Solihull Research Ethics Committee
REC reference
18/WM/0362
Date of REC Opinion
4 Dec 2018
REC opinion
Further Information Favourable Opinion