Morton's neuroma: Manipulation versus steroid injection -Version 3.0.1
Research type
Research Study
Full title
A randomised controlled trial to compare the clinical effectiveness of lower extremity manipulation to that of steroid injection in the treatment of Morton’s Neuroma: A pragmatic study
IRAS ID
129586
Contact name
David Cashley
Contact email
Sponsor organisation
Queen Margaret University
Clinicaltrials.gov Identifier
Duration of Study in the UK
2 years, 2 months, 25 days
Research summary
There is limited research evidence to support the management of Morton's neuroma with steroid injection although its efficacy has only been demonstrated in the short term. To date we have no evidence of any conservative treatment working well for this condition in the long term. This study will investigate whether manipulation offers a better long term result than a steroid injection.
A randomised controlled trial shall be performed. Steroid injection is the current gold standard conservative treatment for this condition. Therefore, manipulation shall be compared to a control group receiving a steroid injection in an equality randomised controlled trial.
Outcomes will be compared using visual analogue pain scales (VAS), The Manchester-Oxford Foot Questionnaire (MOXFQ), The Foot and Ankle Ability Measure (FAAM), the SF-36 quality of life questionnaire and algometric pressure threshold testing. An improvement in either groups’ VAS of 20mm above the other group shall be considered as the minimum worthwhile change as this has been identified as the minimum clinically important difference in pain between treatment groups in visual analogue pain scales.REC name
South East Scotland REC 01
REC reference
15/SS/0099
Date of REC Opinion
15 Jun 2015
REC opinion
Favourable Opinion