Morphology in Supraventricular Tachycardia (MIST)
Research type
Research Study
Full title
ECG Morphology Changes Associated With Supraventricular Tachycardia and Rapid Atrial Pacing: Implications for the Subcutaneous Internal Cardioverter Defibrillator - A Single Centre Observational Study
IRAS ID
203604
Contact name
Benedict M Wiles
Contact email
Sponsor organisation
University Hospital Southampton NHS Foundation Trust
Duration of Study in the UK
1 years, 8 months, 1 days
Research summary
Implantable cardioverter defibrillators (ICDs) are used to prevent sudden cardiac death (SCD) in patients who are felt to be at risk of developing life threatening heart rhythms. They work by continuously analysing a patient's heart rhythm and shocking the heart if required. An entirely subcutaneous ICD (S-ICD) is now available. It has been demonstrated to be both safe and effective.
Supraventricular tachycardias (SVT) are common, non life threatening, rhythm disturbances which originate in the top chambers of the heart. They do not usually require shock treatment. The S-ICD works out whether a fast heart rhythm is an SVT by looking at the appearance (morphology) of the patient's heart tracing (ECG). Unfortunately a proportion of patients will have changes to their ECG when they experience an SVT. This proportion is unknown and SVTs are a common cause of S-ICD patients receiving an inappropriate shock.
This study will analyse what ECG morphology changes occur during SVT and in what proportion of patients. We are also going to test the ability of the S-ICD to identify SVT. This can be achieved by recording a patient's normal ECG, and then recording their ECG during SVT. The ECG during SVT can be analysed by the manufacturers of the S-ICD to identify what the S-ICD would have done if it had seen these rhythms.
An electrophysiology (EP) study is an invasive test which is used to diagnose and treat SVT. During the test patients are stimulated by pacing and medications to produce their SVT. We are therefore going to recruit patients who are already listed for an EP study and ask to monitor their heart during the procedure. We are not going to make any changes to the procedure itself. This will allow us to safely capture the necessary ECGs for each patient.
REC name
West Midlands - South Birmingham Research Ethics Committee
REC reference
16/WM/0182
Date of REC Opinion
10 May 2016
REC opinion
Further Information Favourable Opinion