Molecular Techniques in Oral Potentially Malignant Disorders
Research type
Research Study
Full title
Molecular Techniques in the Study of Oral Potentially Malignant Disorders
IRAS ID
333431
Contact name
Caroline McCarthy
Contact email
Sponsor organisation
University of Liverpool
Duration of Study in the UK
4 years, 11 months, 30 days
Research summary
Patients with "oral potentially malignant disorders" of the mouth have an increased chance of developing oral cancer. Oral cancer is a devastating disease, but if caught early and treated, the survival rates are very good; 90% of people survive for 5 years with early disease, compared to 20% of people with advanced disease. In this long term study, we want to learn more about the risk of oral cancer development in people with pre-cancerous diseases of the lining of the mouth. We will study patients with the following conditions, all reocgnised as Oral Potentially Malignant Disorders (OPMD) by the World Health Organisation: oral lichen planus and oral lichenoid lesions and oral graft vs host disease.
Within Liverpool University Hospitals Trust, we treat patients with all of these conditions across our Oral Medicine and Oral and Maxillofacial Surgery Units. This study will use archived tissue and existing patient data to answer questions about risk factors for cancer development through exploring immune cell infiltration and molecular abberations, using novel techniques available at the University of Liverpool. This will ultimately allow targeted treatments to be developed and offered to the right patients who stand to benefit most. We will not need to take new samples from patients, and will only need to access to archived biopsy samples and clinical records.REC name
London - Chelsea Research Ethics Committee
REC reference
24/PR/0686
Date of REC Opinion
28 Jun 2024
REC opinion
Further Information Favourable Opinion