Molecular Mechanisms of Inflammation in IBD
Research type
Research Study
Full title
An investigation of the molecular mechanisms underlying inflammatory responses in inflammatory bowel disease (Crohn's disease and ulcerative colitis)
IRAS ID
313296
Contact name
Gavin W. Sewell
Contact email
Sponsor organisation
Cambridge University Hospitals NHS Foundation Trust and the University of Cambridge
Duration of Study in the UK
2 years, 11 months, 31 days
Research summary
Crohn's disease and ulcerative colitis are two forms of inflammatory bowel disease (IBD) in which patients develop chronic inflammation primarily affecting the gut, leading to significant symptoms such as diarrhoea, weight loss, abdominal pain and constitutional symptoms. Both genetic and environmental factors are implicated in the development of (IBD) however the mechanisms by which these work and interact cause heightened inflammatory responses is incompletely understood. In this study, we will study intestinal samples from patients with IBD and controls in the laboratory with the aim to uncover how key molecules such as protein components and small molecules might generate over exuberant inflammatory responses in these patients. This will advance our understanding of how these conditions occur which may help uncover novel therapeutic strategies for treating these conditions.
REC name
East of England - Cambridgeshire and Hertfordshire Research Ethics Committee
REC reference
24/EE/0026
Date of REC Opinion
27 Mar 2024
REC opinion
Further Information Favourable Opinion