Molecular genetic analysis of duodenal polyposis in FAP and MAP
Research type
Research Study
Full title
Molecular genetic analysis of duodenal polyposis in the inherited colorectal adenoma and cancer predisposition syndromes (Familial Adenomatous Polyposis and MUTYH-Associated Polyposis)
IRAS ID
158519
Contact name
Laura Thomas
Contact email
Sponsor organisation
Swansea University
Duration of Study in the UK
10 years, 3 months, 31 days
Research summary
Patients with the inherited colorectal adenoma and cancer predisposition syndromes familial adenomatous polyposis (FAP) and MUTYH associated polyposis (MAP) are also at risk of developing malignant and premalignant lesions in other parts of the gastrointestinal tract, particularly the duodenum. Duodenal cancer has become the most common cause of FAP associated death in patients who have had prophylactic colectomy to prevent colorectal cancer.
Understanding of the natural history of duodenal polyposis is limited in both FAP and MAP. In FAP, duodenal disease is staged using the Spigelman classification, which can identify those at high risk of developing duodenal cancer. This is done at surveillance upper gastrointestinal endoscopy, recommended from age 25 or 30 years onwards. The natural history of duodenal polyposis in MAP is less well defined than in FAP, as patients who have developed duodenal cancers have done so on a background of no or minimal duodenal disease.
We aim to determine whether the natural history of duodenal polyposis is the same or different in FAP and MAP and to investigate genetic factors, inherited and somatic, associated with growth and progression of duodenal adenomas to cancer in MAP and FAP.REC name
Wales REC 1
REC reference
15/WA/0075
Date of REC Opinion
16 Mar 2015
REC opinion
Further Information Favourable Opinion