MOH-R: Medication overuse headache in Rheumatology patients.
Research type
Research Study
Full title
MOH-R: Medication overuse headache in Rheumatology patients. A study of pathophysiology with the use of functional neuroimaging.
IRAS ID
271169
Contact name
James Galloway
Contact email
Sponsor organisation
King's College London
Duration of Study in the UK
1 years, 0 months, 1 days
Research summary
Medication overuse headache (MOH) is a well-established cause of chronic daily headache (a term applied for patients with 15 or more headache days a month for more than 3 months) that develops as a consequence of overuse of pain killers. Whether MOH, however, is really a completely distinct disease or medication overuse is triggering an underlying headache problem is a question that has not been fully answered. Rheumatology patients take daily pain killers in a high proportion. The objective is to carry out functional MRI studies to identify differences between three separate groups: patients with medication overuse (MO), patients with MOH from the Rheumatology Clinic who agree to participate and healthy controls.The study design consists of a cross-sectional study of these three separate groups of participants. There will be one visit; the first part of the visit being a screening visit where eligibility will be confirmed through a semi-structured interview. The second part of the study involves a functional brain MRI in eligible patients. The main eligibility criteria are:
Inclusion criteria: Patients with a diagnosis of MO and/or MOH based on the criteria previously published, and aged 30-60 years.
Exclusion criteria: Rheumatoid arthritis patients on a biological treatment as well as any contraindication for the use of a MRI.REC name
London - Harrow Research Ethics Committee
REC reference
19/LO/1772
Date of REC Opinion
17 May 2020
REC opinion
Further Information Favourable Opinion