Mode of Action of Moviprep version 3.0

• Research type

  Research Study

• Full title

  Mode of action of Moviprep:impact on distribution of intestinal fluid and colonic microbiota

• IRAS ID

  59190

• Contact name

  Robin Spiller

• Eudract number

  2010-021879-85

• ISRCTN Number

  N/A

• Clinicaltrials.gov Identifier

  N/A

• Research summary

  Patients often have to take laxatives to clean the bowel before an investigation. We are interested in how these work and whether taking the dose all at once or in divided doses will make a difference. We are also interested in how this bowel cleansing alters the gut bacteria and gut function over time. We plan to use our novel MRI techniques to demonstrate how doses of a preparation designed to clean the bowel alter small and large bowel water content and transit in healthy volunteers. This experimental model is comparable to an episode of acute diarrhoea, therefore this study will also improve our understanding of the effects of diarrhoea on bowel physiology. Following this, we will be recruiting patients who has constipation, who previously do not respond to a laxative, and apply a simplified version of the above study to assess the participant'small bowel water content and how they respond to the bowel cleansing agent.

• REC name

  East Midlands - Nottingham 2 Research Ethics Committee

• REC reference

  11/EM/0440

• Date of REC Opinion

  16 Jan 2012

• REC opinion

  Further Information Favourable Opinion