Mode of Action of Moviprep version 1.0

• Research type

  Research Study

• Full title

  Mode of action of Moviprep:impact on distribution of intestinal fluid and colonic microbiota

• IRAS ID

  59190

• Eudract number

  2010-021879-85

• ISRCTN Number

  N/A

• Clinicaltrials.gov Identifier

  N/A

• Research summary

  Patients often have to take laxatives to clean the bowel before an investigation. We are interested in how these work and whether taking the dose all at once or in divided doses will make a difference. We are also interested in how this bowel cleansing alters the gut bacteria and gut function over time. We plan to use our novel MRI techniques to demonstrate how doses of a preparation designed to clean the bowel alter small and large bowel water content and transit in healthy volunteers. This experimental model is comparable to an episode of acute diarrhoea, therefore this study will also improve our understanding of the effects of diarrhoea on bowel physiology.

• REC name

  North East - Newcastle & North Tyneside 1 Research Ethics Committee

• REC reference

  10/H0906/50

• Date of REC Opinion

  8 Sep 2010

• REC opinion

  Further Information Favourable Opinion