MITOSIS
Research type
Research Study
Full title
Mitochondrial function in the peri-operative setting: an observational Study (MITOSIS)
IRAS ID
319922
Contact name
Anna Clark
Contact email
Sponsor organisation
University Hospital Southampton
Duration of Study in the UK
3 years, 0 months, 1 days
Research summary
Complications after surgery are common and a burden for patients and health services. Therefore it is important that we improve surgical outcomes. Mitochondria are the part of the body’s cells that manage energy. We already know that how our body’s mitochondria behave can predict who survives in intensive care patients. We think this could also predict who is more likely to develop complications after surgery. We have designed a study to find out if changes in mitochondria are related to postoperative complications. This will help us improve how we prepare patients for surgery and potentially how we manage their treatment, and result in improving outcomes for patients after surgery.
This study will recruit patients scheduled for major abdominal surgery as part of their treatment. We will take samples of breath, blood and muscle to measure changes in mitochondria from the day before surgery to 7 days postoperatively. The muscle samples will only be taken when the patient is asleep in theatre or intensive care. We will use these samples to analyse mitochondria. This study will be in two phases. Phase 1 is a pilot of up to 10 patients focussed on feasibility. Following this there will be an interim data analysis. The results may allow further optimisation to reduce the patient burden, eg reduction in sampling frequency, or avoiding need for muscle biopsy. The second phase will be a full cohort study of up to 40 patients, focussed on association of mitochondrial markers with clinical outcomes, such as postoperative complications, oxygen levels, pain, confusion and length of intensive care stay.
The results of this study could improve how we select and prepare patients for surgery. It may also affect how we manage their treatment during and after operations. This could result in reducing complications and illness burden for patients after surgery.
REC name
Yorkshire & The Humber - Leeds East Research Ethics Committee
REC reference
23/YH/0097
Date of REC Opinion
3 May 2023
REC opinion
Further Information Favourable Opinion