Mirror-Box Imaging Study
Research type
Research Study
Full title
Effects of Mirror-Box Therapy on neuroplasticity and functional outcome in hemiparetic upper limb post stroke
IRAS ID
187843
Contact name
Iris Grunwald
Contact email
Sponsor organisation
Southend University Hospital NHS Foundation Trust
Duration of Study in the UK
4 years, 0 months, 1 days
Research summary
Arm and hand weakness as a result of stroke occurs in approximately 70% of stroke survivors, with 30%-60% of patients being unable to fully recover functional use of their upper limbs. As recovery may be due to insufficient or inadequate therapeutic interventions, the progress and evaluation of upper limb treatment is currently being investigated.
Mirror-Box therapy is a task-orientated, non-invasive, economic and patient-directed therapy for hemiparetic upper limb post stroke patients. The study is intended to evaluate cerebral reorganization by using mirror therapy. Movements of the stronger limb trick the brain into thinking that the weaker arm is moving and to stimulate the respective brain areas.
Patients are enrolled into two groups using standard upper-limb rehabilitation for three weeks followed by standard rehabilitation plus Mirror-Box for another three weeks (Group 1). Group 2 will receive the same therapy in inverted order.
Patients will receive clinical and functional assessment at baseline, three weeks and six weeks including brain MRI using functional resting state MRI.
The primary outcome is functional connectivity (correlation coefficient) at baseline and after treatment. Secondary endpoints include motor and functional recovery using outcome measures like Fugl-Meyer assessment, Action Research Arm Test, grip and pincer strength. Further secondary endpoints are increase in sensorimotor cortex activation across the period of therapy and cortical reorganization.REC name
East of England - Essex Research Ethics Committee
REC reference
15/EE/0369
Date of REC Opinion
13 Nov 2015
REC opinion
Further Information Favourable Opinion