MINOH-HF. Evaluating the potential role of minocycline in chronic heart failure
Research type
Research Study
Full title
A feasibility study to evaluate the potential efficacy of minocycline to reduce inflammation, improve autonomic function and increase exercise capacity in chronic heart failure\n
IRAS ID
192609
Contact name
Diana Benton
Contact email
Sponsor organisation
Research and Innnovation, University Hospitals Bristol NHS Foundation Trust
Duration of Study in the UK
1 years, 1 months, 2 days
Research summary
Heart failure is a common condition that reduces both quality and length of life. Blood tests show that people with heart failure have higher levels of inflammation and this is linked with a worse prognosis. \n\nMinocycline, an antibiotic used to treat acne, can reduce this low-level inflammation.\nIn this feasibility study, we want to find out two things: \n1) Can people with heart failure tolerate 3 months of treatment of minocycline? \n2) Can people with heart failure manage the various tests we plan to use? \n\nWe will recruit 10 people with stable heart failure. We will do blood tests to measure their levels of inflammation in the bloodstream. We will assess exercise levels by seeing how far they can walk on a treadmill. We will assess levels of inflammation in the brain by measuring nerve activity using a very fine needle in the leg (like an acupuncture needle).\nPeople taking part will take minocycline for 3 months and then we will repeat the tests.\nWe will use the information from this study to apply for national funding for a larger study to further study the effect of minocycline on inflammation in heart failure. \n
REC name
South West - Central Bristol Research Ethics Committee
REC reference
17/SW/0067
Date of REC Opinion
9 May 2017
REC opinion
Favourable Opinion