mini vs conventional aortic valve replacement and mitral valve repair
Research type
Research Study
Full title
An analysis of systemic inflammatory response, cerebral damage and quality of life after minimally invasive and conventional aortic valve replacement and mitral valve repair.
IRAS ID
290751
Contact name
Hunaid Vohra
Contact email
Sponsor organisation
University of Bristol
Duration of Study in the UK
2 years, 0 months, 1 days
Research summary
The popularity of minimally invasive heart valve surgery continues to grow. Over 14,000 mini-Aortic valve replacement (AVR) operations have been reported in the literature to date. It is well established that cardiac surgery is associated with a systemic inflammatory response, however whether or not minimally invasive techniques have a significant impact on this remains to be determined.
Operative differences between conventional AVR and minimally invasive AVR (mini-AVR) as well as conventional Mitral Valve Repair (MVr) and minimally invasive MVr (mini-MVr), including site of incision, size of incision, manipulation of the aorta, variations in arterial and venous cannulation sites and duration of cardio-pulmonary bypass and cross clamp times are significant. We hypothesize that these differences may lead to reduced levels of systemic inflammatory response and cerebral injury in the minimally invasive group.
We will select 80 patients from the OMACS database who have undergone a AVR or MVr procedure and have donated blood and urine samples for future research. For laboratory analysis, patients will be split into four groups: cAVR (n=20), mini-AVR (n=20), cMVr (n=20) and mini-MVr (n=20). We will then compare levels of serum and urinary biomarkers between the conventional and minimally invasive groups at various time-periods before and after surgery.
The OMACS study also issues quality of life questionnaires to patients at 3 and 12 months post cardiac surgery. We will collate and analyse these responses to assess whether there is any reported differences between the conventional and minimally invasive groups and describe general quality of life after cardiac surgery.
REC name
Yorkshire & The Humber - Bradford Leeds Research Ethics Committee
REC reference
21/YH/0280
Date of REC Opinion
5 Nov 2021
REC opinion
Favourable Opinion