MIMOSA: Morphine in Moderate Obstructive Sleep Apnoea
Research type
Research Study
Full title
The effect of acute intravenous (iv) morphine administration on Sleep Disordered Breathing (SDB) in patients with moderate Obstructive Sleep Apnoea (OSA): A paired design trial
IRAS ID
148632
Contact name
Martina Mason
Contact email
Sponsor organisation
Papworth Hospital NHS Foundation Trust - Research and Development Department
Eudract number
2014-001950-41
Duration of Study in the UK
1 years, 5 months, 28 days
Research summary
Obstructive Sleep Apnoea (OSA) is a condition caused by repetitive narrowing/collapse of the upper airway leading to reduction/pauses in airflow during sleep causing intermittent drop of blood oxygen levels.
This study will investigate the effects of morphine (a drug commonly used for pain relief, including following surgery) on the severity of OSA, measured by Apnoea Hypopnea Index (AHI, number of pauses in breathing per hour of sleep causing significant drops in blood oxygen levels). OSA is common in the adult population and many sufferers are undiagnosed. It is therefore likely patients presenting for surgery (and therefore are prescribed morphine for pain relief following surgery) will have undiagnosed/untreated OSA.
Potential patients with moderate OSA established on Continuous Positive Airway Pressure (CPAP, a treatment for OSA) will be recruited to the study. Patients will be risk assessed as to their safety to withdraw from CPAP by the study doctor and if safe to do so, will stop CPAP treatment for 6 nights prior to a home sleep study (rPSG, respiratory polygraphy) and the study visit (an overnight inpatient admission) To ensure patient safety, a delegated doctor will be present throughout the whole night and will observe patient's respiration. Recruitment will continue until 26 patients with moderate OSA have succesfully completed the study night (overnight inpatient admission)
The primary outcome will be change in AHI from baseline to study rPSG. Secondary outcomes include the change in various respiratory variables from baseline to study rPSG.
REC name
East of England - Cambridgeshire and Hertfordshire Research Ethics Committee
REC reference
15/EE/0194
Date of REC Opinion
30 Jun 2015
REC opinion
Further Information Favourable Opinion