MicroRNA Expression and Function in Psoriasis II

• Research type

  Research Study

• Full title

  MicroRNA Expression and Function in Psoriasis II

• IRAS ID

  163330

• Contact name

  Kehinde Ross

• Contact email

  o.k.ross@ljmu.ac.uk

• Research summary

  MicroRNA Expression in Psoriasis
  Increasing scientific evidence suggests that complex diseases like psoriasis are driven by small gene products called microRNAs. These molecules acts as "dimmer switches" that turn down gene expression. Alterations in microRNA levels in psoriatic skin compared to normal skin may contribute to the disease. In this study, the amounts of microRNAs in lesional and non-lesional psoriatic skin will be examined. Patients (no systemic treatments for at least 2 weeks and no active topical treatments apart from emollients for 1 week) will be recruited will be recruited from the Royal Liverpool and Broadgreen University Hospitals NHS Trust Dermatology clinic. Biopsies (6 mm) will be obtained under local anaesthesia from Biological molecules (RNA and microRNA) will be extracted using routine methods, and levels of these molecules will be assessed using established techniques. Together, with additional laboratory investigations, these studies will support the development of microRNA-based therapy for psoriasis.

• REC name

  London - Fulham Research Ethics Committee

• REC reference

  14/LO/1711

• Date of REC Opinion

  19 Sep 2014

• REC opinion

  Further Information Favourable Opinion