Microbiome and Metabolome in Healthy Volunteers (MATINEE Study)
Research type
Research Study
Full title
Investigating the stool and saliva microbiome and metabolome in healthy volunteers (The MATINEE Study). An observational cohort study.
IRAS ID
322270
Contact name
Philip Molyneaux
Contact email
Sponsor organisation
Imperial College London
Duration of Study in the UK
1 years, 11 months, 30 days
Research summary
This cohort study aims to assess the microbiome (the community of bacteria) of the gut and oral cavity of healthy volunteers. This will allow us to compare these communities to those of patients with interstitial lung disease (ILD), who are thought to have a disordered microbiome. If we find differences between the microbiome between healthy volunteers and ILD patients, it may facilitate earlier diagnosis from screening tests or even for potential targets for treatment.
This study will be run from the Royal Brompton Hospital. Participants will be recruited from the general population and will be offered £25 per study visit. Any individual between the age of 18-99 without a history of respiratory disease is eligible for participation. Smokers and ex-smokers are eligible as long as they have no current respiratory condition. The study aims to collect oral and stool samples at baseline, and at 3 and 12 months after the initial visit. It is therefore anticipated that samples collection will take up to two years. Participants will be sent collection kits in the post with stamped return packages so will not need to attend the hospital. Samples will be analysed to assess the types of bacteria present.
A full medical history will be obtained to establish whether participants have any history of respiratory disease, take any medications or have any diagnoses that may alter the microbiome. At each sampling point a repeat medical history will be taken and participants will be sent an online questionnaire including a three-day food diary and food frequency questionnaire.REC name
Yorkshire & The Humber - Leeds West Research Ethics Committee
REC reference
23/YH/0114
Date of REC Opinion
10 Jul 2023
REC opinion
Further Information Favourable Opinion