Methods of predicting RMF and need for NIV in MND V1
Research type
Research Study
Full title
What is the most effective physiological parameter in detecting a deterioration in respiratory function in patients with Motor Neurone Disease (MND)?
IRAS ID
245778
Contact name
Scott Davidson
Contact email
Sponsor organisation
NHS Greater Glasgow and Clyde
Duration of Study in the UK
0 years, 9 months, 24 days
Research summary
Respiratory failure is the leading cause of death in patients with Motor Neurone Disease (MND). In MND, respiratory failure occurs due to weakness in the respiratory muscles, thus making it difficult to breathe. To aid with breathing, ventilation is delivered by a machine via a face mask. Providing breathing support has been shown to treat respiratory failure, increase quality of life and improve prognosis. \nIn practice it can be difficult gauging when to initiate breathing support. Initiation usually occurs once; respiratory muscle weakness has been highlighted via breathing tests, raised daytime blood carbon dioxide levels and symptoms of breathlessness. Patients are therefore generally symptomatic by the time breathing support is commenced. Hence, it would be beneficial to know which tests, if any, can highlight a decline in respiratory function early. This could potentially indicate which patients may develop respiratory muscle failure in the future. The purpose of this study is to determine which physiological test is the most effective at detecting an early marker of decline in respiratory function. Four tests: spirometry, sniff nasal inspiratory pressure, capillary blood gas and daytime spot check/overnight skin probe monitoring of oxygen and carbon dioxide will be carried out at 3 month intervals (day 1, 3 months and 6 months). Statistical analysis will determine if any test detects a marker of decline in respiratory function earlier than the other. Change in respiratory function over time will be analysed. MND patients attending respiratory clinic appointments at the Queen Elizabeth University Hospital will be screened for eligibility.\nThis research aims to streamline the diagnosis of respiratory weakness in MND patient
REC name
West of Scotland REC 1
REC reference
18/WS/0158
Date of REC Opinion
1 Oct 2018
REC opinion
Further Information Favourable Opinion