Method development for measuring oral hypoglycaemic agents in serum.
Research type
Research Study
Full title
The Development of a Liquid Chromatography - Tandem Mass Spectrometry Method for the Detection and Measurement of Oral Hypoglycaemic Agents in Serum.
IRAS ID
223789
Contact name
Kate E Fenna
Contact email
Sponsor organisation
NHS
Duration of Study in the UK
0 years, 3 months, 0 days
Research summary
This study is a method development to establish a suitable laboratory method that can be used for both the detection and quantification of oral hypoglycaemic medication at the Royal Surrey County Hospital (RSCH) peptides laboratory. The RSCH is well placed to conduct this study due to the excellent facilities in the specialist Peptides Laboratory where the blood analyses can be carried out. This laboratory provides a Supra-regional Assay Service and therefore this project will develop a method to enhance the services provided to all service users. Patients that take the 6 main oral hypoglycaemic medications prescribed in the UK to control their blood glucose will be recruited during routine clinic visits at the RSCH, and a single 15mL blood sample will be obtained. This sample will be used to develop a laboratory method termed Liquid Chromatography - Tandem Mass Spectrometry (LC-MS/MS) that can be used to provide a service at the RSCH Peptides Laboratory for detecting and measuring 6 different oral hypoglycaemic drugs in the blood. Once established the method will be routinely used for medication monitoring, ruling out medication caused hypoglycaemia, ruling out medication caused lactic acidosis and as part of the international forensic work currently performed at the laboratory.
REC name
North East - Newcastle & North Tyneside 1 Research Ethics Committee
REC reference
17/NE/0237
Date of REC Opinion
11 Jul 2017
REC opinion
Favourable Opinion