Metabonomic analysis of cART efficacy in urine from HIV patients
Research type
Research Study
Full title
Optimising metabonomic analysis to monitor ART efficacy in urine samples from HIV patients
IRAS ID
187280
Contact name
Myra McClure
Contact email
Duration of Study in the UK
0 years, 6 months, 17 days
Research summary
We aim to recruit 20 patients who are HIV positive, currently taking combination ART, and have at least two undetectable viral load. We want to analyse their first-pass morning urine samples for 5 consecutive days, plus 5 more samples over a course of 10 weeks. The small molecules, i.e. metabolites, in their urines will be measured using NMR spectroscopy and liquid chromatography-mass spectrometry. In this way, we can assess the daily variability in metabolites present in the urine to establish baseline levels in patients who are stable on ART with undetectable viral load.
REC name
London - Bromley Research Ethics Committee
REC reference
15/LO/1584
Date of REC Opinion
4 Sep 2015
REC opinion
Favourable Opinion