MET-REPAIR-FRAILTY v1.0

• Research type

  Research Study

• Full title

  MET-REPAIR-FRAILTY: Frailty substudy of MET: REevaluation for Perioperative cArdIac Risk (MET-REPAIR)

• IRAS ID

  230478

• Contact name

  Simon Howell

• Contact email

  S.Howell@leeds.ac.uk

• Sponsor organisation

  University of Leeds

• Duration of Study in the UK

  0 years, 11 months, 30 days

• Research summary

  MET-REPAIR-FRAILTY is a UK-based sub-study of an international multicentre prospective cohort study (MET-REPAIR). Whereas MET-REPAIR will look at whether adverse perioperative cardiac outcomes are associated with estimation of a patient's functional capacity through questionnaire, MET-REPAIR-Frailty will investigate whether there is a link between adverse cardiovascular outcome and patient frailty.
  
  There are a number of clinical tools that assess a patient’s degree of frailty. However, it is unclear which of these assessment tools is the most useful in risk prediction in the preoperative setting.

  The primary objective of the study is to determine, for patients undergoing high-risk non-cardiac surgery, whether assessment of frailty assists prediction of perioperative cardiovascular events or mortality. It will investigate whether frailty assessment improves prediction of risk independently and/or in combination with estimation of a patient's functional capacity through metabolic equivalents (using data gathered in the MET-REPAIR study). If an association with frailty does exist, it will further add to the methods available for establishing a patient’s risk of morbidity or mortality when they undergo major elective surgery.

  This study will include participants of 45 years of age or older, undergoing elective high-risk noncardiac surgery, or aged 65 years and older undergoing intermediate or high-risk procedures. It will be carried out in hospital trusts that provide elective high-risk surgery. Patients will be assessed using three frailty assessments; one of which is a clinician-based judgement, and two which entail a combination of patient-reported symptoms and functional tasks. Outcome data will subsequently be collected after surgery. This will be a multi centre study within the UK, and will run concurrently alongside the MET-REPAIR study.

• REC name

  London - Westminster Research Ethics Committee

• REC reference

  18/LO/1082

• Date of REC Opinion

  2 Jul 2018

• REC opinion

  Favourable Opinion