Memantine: Pilot Study of Memantine in chronic cough patients
Research type
Research Study
Full title
Open-label Pilot Study of Memantine in Chronic Cough Patients Attending a Specialist Clinic
IRAS ID
85525
Contact name
Jaclyn Smith
Contact email
Sponsor organisation
University of Manchester
Eudract number
2011-005151-13
ISRCTN Number
0
Clinicaltrials.gov Identifier
0
Research summary
People cough in order to clear their airways. Most coughs are caused by viruses and settle down by themselves, but some people develop persistent coughing which can last for many years. This is called chronic cough. People with chronic cough find the symptom very upsetting and it can have a major impact on their quality of life. There are currently no effective treatments for chronic cough. People with chronic cough often have sensitive airways and we are interested in developing medications which reduce this sensitivity. This study aims to investigate whether a drug called Memantine helps to reduces coughing. Memantine is a similar medication to that found in many over-the-counter treatments for cough (Dextromethorphan). Memantine is currently licensed to treat patients with Alzheimer??s disease. It has never been tested on patients with chronic cough. Fifteen patients attending the specialist chronic cough service at Wythenshawe Hospital will be invited to attend the North West Lung Research Centre up to 7 times over a maximum 8 week period. During the course of the study they will be asked to take increasing doses of Memantine, have a blood test, electrocardiogram, undergo 24 hour cough monitoring and answer cough related questionnaires.
REC name
North West - Haydock Research Ethics Committee
REC reference
11/NW/0840
Date of REC Opinion
20 Dec 2011
REC opinion
Favourable Opinion