MEGAbIT - The role of MEG in Assessment and diagnosis In mTBI
Research type
Research Study
Full title
The role of MEG in Assessment and diagnosis In mTBI. An observational study
IRAS ID
256907
Contact name
Nikos Evangelou
Contact email
Duration of Study in the UK
1 years, 0 months, 0 days
Research summary
Head injuries are responsible for 1.4 million visits to hospital each year in the UK. Most patients are allowed home the same day and make a full recovery, but some will have persistent symptoms. We aim to use the latest generation of imaging technology to investigate those with acute traumatic brain injury (TBI) to better assess them.
We will invite patients presenting following trauma to the Emergency Department at Queen's Medical Centre, Nottingham to participate. We will compare those who have a suffered a TBI to those who have injuries elsewhere. We will use two magnetoencephalogram (MEG) systems and ultra-high field magnetic resonance imaging (MRI) to record the functioning and structure of the brain within days of their injury. We will test memory and thinking skills, then follow participants for six months, record the severity of their symptoms, and find out who does not make a full recovery.
We will test whether these innovative imaging techniques are more sensitive to the damage that TBI causes than routine imaging. We will also test whether early imaging can reveal who is most seriously affected, identifying those who will not recover without additional support. It is currently not clear what the predominant mechanism of damage that causes these long-term problems is and we hope our study will address this. The Medical Research Council is funding this work
REC name
Wales REC 6
REC reference
19/WA/0085
Date of REC Opinion
11 Apr 2019
REC opinion
Further Information Favourable Opinion