Mechanisms of Immunometabolic dysfunction in severe CoViD-19
Research type
Research Study
Full title
Profiling mitochondrial and adipose tissue function to understanding the mechanisms of metabolic and immune dysfunction associated with severe Covid-19 infection.
IRAS ID
291251
Contact name
Malcolm Watson
Contact email
Sponsor organisation
NHS Greater Glasgow and Clyde Health Board
Duration of Study in the UK
1 years, 0 months, 1 days
Research summary
We are primarily interested interested in analysing the blood and fat cells of those COVID positive patients in critical care and secondarily COVID negative patients scheduled for bariatric and appendectomy surgery. Priliarily we wish to ascertain if there are any metabolic-related differences in inflammation in the fat cells between obese COVID-19 positive and obese COVID-19 negative patients scheduled for elective bariatric sue=rgery.
We will take blood samples and a single small sample of fat from under the skin in the abdomen. This will be analysed to look at the mitochondrial function of the fat tissue and blood cells and the structure of the fat cells and the inflammatory molecules they are producing.
We aim to better understand the relationship between metabolic dysfunction associated with obesity, age diabetes, and cardiovascular disease and severe CoViD-19 infection. This will direct future clinical research to targeted interventions such as weight loss drugs, immune therapies, and vitamin supplements in the case of mitochondrial dysfunction.REC name
North of Scotland Research Ethics Committee 2
REC reference
21/NS/0015
Date of REC Opinion
16 Feb 2021
REC opinion
Further Information Favourable Opinion