Measuring Proteins Contributing to Renal Stone Formation
Research type
Research Study
Full title
Measurement of Circulating and Cellular Proteins and their Role in Renal Stone Formation
IRAS ID
110313
Contact name
James Graham Young
Contact email
Sponsor organisation
University hospital south manchester
Research summary
Renal stones are common and are the cause of many hospital admissions due to associated severe pain and infection. More recently, renal stones have also been found to be associated with renal stones such as atherosclerosis, impairment of the immune system and chronic kidney disease. We aim to investigate the role of protein molecules in renal stone formation and the precise role they play in this mechanism. Past studies have investigated some molecules present in the urine and the kidney and how they affect the formation of a kidney stone, but the exact mechanism of renal stone formation is still only partly understood. Here at UHSM, we have access to large numbers of urine samples, biopsies and serum samples that are taken as part of routine patient care in stone patients. The Urology unit at UHSM can therefore greatly utilise these samples to investigate the mechanisms of stone formation. There are various different types of stones and they are all formed as a result of different processes that occur within the body physiologically. We therefore aim to interrogate these key molecules and processes which predispose indviduals to renal stone formation.
REC name
North West - Preston Research Ethics Committee
REC reference
13/NW/0339
Date of REC Opinion
5 Jul 2013
REC opinion
Further Information Favourable Opinion