Measuring Disease in Heart Vessels With New Imaging Device (MOUSA)V1.4

• Research type

  Research Study

• Full title

  Multimodality Optical and Ultrasound Intravascular Imaging for Stent Optimization and Atheroma Assessment

• IRAS ID

  268761

• Contact name

  Christos Bourantas

• Contact email

  c.bourantas@nhs.net

• Sponsor organisation

  Barts Health NHS Trust,

• Clinicaltrials.gov Identifier

  NCT05753085

• Duration of Study in the UK

  2 years, 2 months, 31 days

• Research summary

  Does the NovaSight hybrid imaging catheter improve the assessment and treatment of heart attack patients who need a stent?

  Fatty substances called plaques can clog the coronary (heart) arteries. The plaques may slow or stop blood flow to the heart muscle. If the artery is partly blocked by plaques, a person may have chest pain. When the artery becomes completely blocked, a person has a heart attack. There are different types of plaques. Some are more likely to progress and cause a heart attack.

  Currently plaques are assessed by two types of imaging catheters. One uses ultrasound (IVUS) the other uses light (OCT) to produce different types of pictures of the heart arteries and plaques. Each type on their own do not provide a full picture. The Novasight Hybrid imaging catheter provides both types of images in one go. We think this will improve assessment and deciding when treat plaque with stents.

  We will
  See how well this new hybrid catheter works compared with the separate IVUS and OCT catheters.
  See if we can better identify plaques that might cause future problems
  See how safe and effective it is.
  Develop new ways to process and use the images from the hybrid catheter

  Barts Charity, Rosetrees and the Barts BRC are funding the study at Barts Health NHS Trust.
  50 heart attack patients who need a stent will have images of their heart vessels taken during their treatment using this new hybrid imaging catheter. All participants will be followed up by telephone up to 1 year. 20 patients will be asked to have extra assessments of the heart arteries during their initial treatment and to have the same assessments again at 1 year.
  
  We hope the hybrid catheter provides a better assessment of the plaque to help improve the treatment and prevent future problems.

• REC name

  London - Brent Research Ethics Committee

• REC reference

  23/LO/0454

• Date of REC Opinion

  3 Jul 2023

• REC opinion

  Further Information Favourable Opinion