(May) Cortical evoked potentials in auditory processing disorders

• Research type

  Research Study

• Full title

  Auditory cortical evoked potentials in the diagnostic test battery for auditory processing disorder

• IRAS ID

  86417

• Contact name

  Doris-Eva Bamiou

• Contact email

  D.Bamiou@ucl.ac.uk

• Sponsor organisation

  Great Ormond Street Hospital for Children NHS Foundation Trust & ICH

• Research summary

  Auditory Processing Disorder (APD) is a hearing/listening disorder resulting from abnormal brain function that may be associated with communication, learning, behavioural, emotional, and social difficulties. APD is diagnosed on the basis of hearing tests that require a response from the child (behavioural or subjective), tests that assess the brain’s activity in response to sound (electrophysiological or “objective“) and additional assessments of language and cognition. This study will investigate if the electrical activity of the top part of the brain in response to complex sounds (ie “auditory cortical evoked responses“ referred to as EEG) is different in children with APD vs. normal age matched children, and if so, how good this test is in diagnosing APD.
  Aims: To identify impairment(s) underlying an APD and behavioural/EEG test paradigms for APD assessment that can be used in the clinic. To identify the brain parts (identified by analysing which parts of the top brain generate the auditory cortical responses -EEG ) that underpin test performance and clinical symptoms.

  We will conduct auditory cortical evoked responses (EEG) and behavioural tests in 30 children with a diagnosis of APD from the Great Ormond Street Hospital Audiological Medicine clinic, and on 30 age and sex matched normal controls. We will compare these responses in the two groups to see if these are different and we will examine which response parameters and criteria are best in differentiating APD from non-APD children, and with what percentage of correct and false diagnostic hit rate (sensitivity and specificity). We will also conduct similar to the auditory, visual evoked responses to assess whether any electrophysiological abnormalities are specific to the auditory modality.

• REC name

  London - Queen Square Research Ethics Committee

• REC reference

  13/LO/0627

• Date of REC Opinion

  28 Jun 2013

• REC opinion

  Further Information Favourable Opinion