MASDA (Marker for Autism Spectrum Disorders based on EEG Analysis)
Research type
Research Study
Full title
New marker for autism spectrum disorders in children based on the nonlinear analysis of complexity, coherence and synchronization in EEG waves - a feasibility study
IRAS ID
126409
Contact name
Aneta Stefanovska
Contact email
Research summary
The central aim of the project is to establish whether modern nonlinear analysis techniques can reveal autism spectrum disorders in EEG (electroencephalograph) waves measured from children diagnosed with this condition. In order to achieve this, brain waves of young children with a diagnosis of an autism spectrum disorder will be compared with the brain waves of similar young children who have no developmental problems.
Researchers in Lancaster involved in this project have developed a technique to interpret the electrical signals produced by the brain in a new, more detailed and more sophisticated way. These signals, or brain waves, are measured by an EEG,a painless procedure using sensors pasted to the scalp. Recent research suggests that it may be possible to identify a difference in the pattern of these electrical signals in individuals with an autism spectrum disorder (ASD) from those seen in individuals without this condition. The specialised analysis techniques that will be used in this study increase the likelihood that any differences will be detected.
Diagnosis of autism spectrum disorders currently depends on the clinical recognition of significant problems with an individual’s communication, social interaction and flexible thought processes. There is no definitive test to confirm or rule out the diagnosis. Finding a way of making the diagnosis before symptoms are well established may increase the impact of interventions. It will also prevent the sometimes prolonged uncertainty that some parents experience before a diagnosis can be made or dismissed.
The proposed work focuses on child health, and is highly innovative. It lies at the interface between basic research on brain development and function, and applications in clinical practice. Improved understanding will pave the way to more reliable and earlier diagnosis of ASD, as well as possible therapy aimed at arresting or reversing the development of this condition.
REC name
North West - Preston Research Ethics Committee
REC reference
13/NW/0509
Date of REC Opinion
16 Jul 2013
REC opinion
Favourable Opinion