MANE: Myocardial Injury After Radical Nephrectomy
Research type
Research Study
Full title
MANE: Myocardial Injury After Radical NEphrectomy
IRAS ID
334214
Contact name
EM Quintela
Contact email
Sponsor organisation
Sheffield Teaching Hospitals NHS FT
Duration of Study in the UK
1 years, 5 months, 0 days
Research summary
Kidney removal for cancer (nephrectomy) is a major operation. People can develop heart complications during or after surgery, especially if they are older or already have heart disease. One form of heart damage is called myocardial injury (MINS). This can be detected with a simple and easily available blood test. Unlike a heart attack, MINS doesn’t cause changes in the electrical tracing of the heart (ECG) and it typically doesn’t cause symptoms like pain. However, it can lead to heart problems and a stroke after surgery. We do not know how many people having a nephrectomy develop MINS. It is important to know if people are at high risk of MINS to help decide future treatment.
There are a few different ways of carrying out nephrectomy surgery. These can be traditional open surgery, keyhole surgery or robotic surgery. We know that MINS is more likely if there has been a lot of bleeding during the operation, but other factors are also important. Therefore, it's important to monitor the relationship between blood loss, rates of MINS and method of surgery.
We aim to recruit 120 participants undergoing nephrectomy to see how many develop MINS and to compare blood loss between different ways of surgery. Patients will be asked to consent to have blood tests on the day of and the day after surgery. This test will be added to routine hospital blood tests (and so in most cases, no extra samples are needed). These results will show how many patients are diagnosed with MINS after nephrectomy. Around 90 days after the surgery, their quality of life and any further heart or breathing problems will also be recorded.
We hope to identify the rates of and risk factors for MINS, so future patients can be spared this complication of surgery.
REC name
Wales REC 7
REC reference
24/WA/0025
Date of REC Opinion
12 Feb 2024
REC opinion
Further Information Favourable Opinion