MAN01 Alpha Blockers in Allergic Rhinitis Version 1.0
Research type
Research Study
Full title
A proof of concept study in allergic rhinitis, to evaluate the differential effects of doxazosin between single and chronic dosing on nasal airway calibre
IRAS ID
120251
Contact name
Arvind Manoharan
Contact email
Sponsor organisation
University of Dundee
Eudract number
2012-005035-85
Research summary
Allergic rhinitis (allergic inflammation of the nose) is a common medical condition which is known to seriously decrease quality of life, aggravate pre-existing conditions particularly asthma, carry significant medical treatment costs and be responsible for reduced work productivity and lost school days. A significant symptom of the condition, nasal blockage, remains difficult to treat even when using nasal corticosteroids. Decongestant medications act on the blood vessels in the nose and have an immediate effect in clearing a blocked nose but if used for more than seven days a more severe rebound congestion of the nose develops. In this study, we aim to assess the effects of doxazosin, a drug which is currently used to treat high blood pressure and symptoms of prostate enlargement, to find out if it has an effect on nasal blockage.
REC name
East of Scotland Research Ethics Service REC 2
REC reference
13/ES/0010
Date of REC Opinion
2 Apr 2013
REC opinion
Further Information Favourable Opinion