MAMMO-50 version 1.0 [date]
Research type
Research Study
Full title
MAMMO-50: Mammographic surveillance in breast cancer patients aged 50 years and over
IRAS ID
134352
Contact name
Janet Dunn
Contact email
Research summary
The Government`s 2007 Cancer Reform Strategy recommends breast cancer patients be supported in self-care and have personalised risk-adjusted follow-up to meet their needs. As young age is a strong predictor of invasive and non-invasive “second“ breast cancer (ie recurrence on treated side or new cancer in opposite breast), current NICE guidance (2009) recommends patients diagnosed up to age 50 years have mammograms annually. For those patients aged 50 or older, there is no clear evidence or consensus amongst specialists on risk-factors to advise the optimum frequency or duration of follow-up mammograms.
Type of breast surgery (mastectomy or conservation) does not affect long term survival. However, 3 years after diagnosis, second breast cancers are found less frequently by mammography in mastectomy patients than those patients who have had conservation surgery. Early detection of second cancers or metastasis is more likely to occur via patient self-examination between mammograms than by specialist clinic visits. A patient’s ability to self-check and report concerns could be improved by alternative follow-up regimens including questionnaires and/or contact with nurses GPs, radiographers or internet access.
In order to provide sound evidence for future management, this clinical trial aims to establish if patients aged 50 years or over, can be identified who require less frequent mammographic surveillance whilst investigating alternative methods of follow-up.
The study will therefore randomise patients to either annual mammography until 9 years post- surgery, or every 2 years after conservation surgery or 3 years after mastectomy until year 9 post-surgery, to establish if they are no worse off in terms of detection of second breast cancer or quality of life as compared to patients who continue with annual mammograms. Eligible patients for whom the specialist or patient opts for standard mammography per local practice will be given the option to participate in the Observational Cohort Study.
REC name
West Midlands - Coventry & Warwickshire Research Ethics Committee
REC reference
13/WM/0419
Date of REC Opinion
11 Dec 2013
REC opinion
Further Information Favourable Opinion