Lung HeXeRT
Research type
Research Study
Full title
Lung HeXeRT: Advanced proton, hyperpolarised 3-helium and 129-xenon magnetic resonance imaging for lung cancer radiotherapy planning and evaluation
IRAS ID
125782
Contact name
Matthew Hatton
Contact email
Sponsor organisation
University of Sheffield
Clinicaltrials.gov Identifier
Research summary
The University of Sheffield is one of the leading centres in the world for basic and translational research with inhaled gas MRI, which provides lung images with unprecedented spatial and temporal resolution. Our previous work demonstrated that inhaled gas MRI can provide significant clinical information for lung cancer radiotherapy planning and post-treatment evaluation. Building upon this unique experience, a multidisciplinary team will conduct an inhaled gas and proton lung MRI study that will address two of the major clinical problems faced by lung cancer patients treated with radiotherapy.
1. Normal lung tissue is often damaged by the curative radiation dose. We hypothesise that regional ventilation-perfusion lung function imaging with inhaled gas and proton MRI before and after treatment will help to lower the risk of radiation-induced lung injury and help to detect such damage at an early stage.
2. Identification of the extent of cancerous tissue is error-prone when planning treatment from CT images alone. We hypothesise that advanced proton MRI techniques will improve the identification of tumour volume, which is critical to successfully targeting the radiation dose.
To achieve these goals, image acquisition and image processing methods will be tested with a study of 20 patients. Results from this study will make an important contribution to improving the treatment of lung disease which is one of the key research priorities of the NHS.REC name
Yorkshire & The Humber - South Yorkshire Research Ethics Committee
REC reference
13/YH/0191
Date of REC Opinion
1 Jul 2013
REC opinion
Favourable Opinion