LUCIDITY

• Research type

  Research Study

• Full title

  Lung Ultrasound in Coronavirus and Intermittent haemoDialysIs sTudY: LUCIDITY

• IRAS ID

  284786

• Sponsor organisation

  South Tyneside and Sunderland NHS Foundational Trust

• Duration of Study in the UK

  0 years, 5 months, 25 days

• Research summary

  The title of this study is “Lung Ultrasound in Coronavirus and Intermittent haemoDialysIs sTudY (LUCIDITY)”. This study aims to differentiate the lung ultrasound (LUS) findings of COVID-19 patients and end-stage renal disease (ESRD) patients on maintenance haemodialysis (MHD). Haemodialysis is a regular treatment given three times a week to replace the job of their kidneys.

  We will study patients who receive their scheduled outpatient dialysis at Sunderland Royal Hospital (SRH). Some of these patients currently or recently have had coronavirus.

  COVID-19 has a specific appearance on LUS which we think are different enough to be able to distinguish from lung congestion. It is not clear how long these changes last but it is thought to be a number of weeks to months.

  Lung congestion is also associated with a number of other common causes of breathlessness such as heart disease, this is a common cause for hospital admission. Previous research shows patients with lung congestion have LUS appearances that change before and after MHD – making them a more suitable study group compared to the general population of people with lung congestion.
  Our research will focus on attempting to distinguish between lung congestion and active or recent COVID-19 disease, the investigators would not know who has had COVID-19.

  It would involve a LUS before and after their regular dialysis treatment assessing each time if we think changes are related to lung congestion, COVID-19 or both. This data will be cross-referenced and analysed with their recent medical notes.
  It would be useful to know if COVID-19 can be distinguished from other causes of breathlessness with LUS (such as lung congestion in patients with heart disease) as this is a simple, quick and safe bedside test. This would potentially help with the rapid detection and triage of patients with suspected COVID-19.

• REC name

  East Midlands - Nottingham 1 Research Ethics Committee

• REC reference

  20/EM/0156

• Date of REC Opinion

  12 Jun 2020

• REC opinion

  Favourable Opinion