LPR Fluoresence Pilot
Research type
Research Study
Full title
Analysis of mouthwash samples from laryngopharyngeal reflux (LPR) patients and healthy volunteers using barrel-array diagnostics
IRAS ID
310446
Contact name
Anthony Hobson
Contact email
Sponsor organisation
Functional Gut Clinic
Duration of Study in the UK
0 years, 9 months, 31 days
Research summary
Laryngopharngeal reflux (LPR) is a condition where stomach contents go up beyond the oesophagus into the ear, nose, throat, mouth and airways. This leads to inflammation and troublesome symptoms including cough, breathlessness, sore throat, hoarseness and sour taste. Recently, biomarkers from non-invasive bodily samples, such as saliva, have become of interest for the detection of inflammatory and pre-cancerous or cancerous conditions. We aim to see if the biosensing platform Pandra, developed by Rosa Biotech, can distinguish patients with LPR from healthy volunteers due to expected inflammation and cell changes in the laryngo-pharyngeal (throat) region.
To do this, patients with LPR and healthy volunteers without LPR will provide a mouthwash (salivary oral rinse) sample, which will be analysed using Pandra. The study will take place at the Functional Gut Clinic, a non-NHS site, that sees patients referred for diagnostic investigations. All adult patients referred to the Functional Gut Clinic for reflux testing as part of their standard care pathway may be eligible to take part. The study also involves the use of questionnaires to determine reflux symptom severity and accompanying digestive disorders.
REC name
North West - Greater Manchester West Research Ethics Committee
REC reference
22/NW/0031
Date of REC Opinion
9 Mar 2022
REC opinion
Further Information Favourable Opinion