Low radiation dose Computer Tomography (CT) assessment of TSA
Research type
Research Study
Full title
Low radiation dose Computer Tomography (CT) assessment of Total Shoulder Arthroplasty
IRAS ID
187252
Contact name
Ravi Popat
Contact email
Sponsor organisation
Imperial College London
Duration of Study in the UK
2 years, 11 months, 31 days
Research summary
The longevity of implants remains the main issue following Total Shoulder Replacement (TSR). A meta-analysis by Bohsali et al reported the incidence of loosening in the absence of infection to be 39%. We are trying to understand the ‘performance’ of Total Shoulder Replacement over the first 2 years of implantation, using low radiation dose CT scans to provide information on factors such as how much the implant moves are insertion (migration), how well the implant bonds to the bone (osseointegration) and how the bone responds to the implant (stress shielding).
Two factors have been shown to be strongly linked with implant loosening; early migration of implants the incidence of radiolucent lines.
Conventional radiographs have been shown to provide inaccurate information as it assesses the component’s 3D migration using a 2D projection.
The aim of this study is to develop an imaging protocol that uses Computed Tomography (CT) scanning to give high quality images and information about migration and radiolucent lines with different types of Total Shoulder Replacements.
We have designed the protocol so that the radiation dose is low enough for us to safely perform the required number of scans to monitor the fixation of Total Shoulder prostheses.
REC name
London - Queen Square Research Ethics Committee
REC reference
15/LO/1899
Date of REC Opinion
8 Jan 2016
REC opinion
Further Information Favourable Opinion