LoPhos Study (Long hours hemodialysis and Phosphate study)
Research type
Research Study
Full title
Effect of long hours haemodialysis on phosphate clearance and FGF23-klotho axis
IRAS ID
164133
Contact name
Alastair Hutchison
Contact email
Sponsor organisation
Central Manchester University Hospitals NHS Foundation Trust
Duration of Study in the UK
0 years, 6 months, 31 days
Research summary
Phosphate is one of the toxins that get accumulated in the body in kidney failure. Conventional 4 hours X 3 times a week dialysis does not clear phosphate well. Long hours dialysis (8 hours) is better at clearing phosphate. Phosphate kinetics is very complex, so it has not been possible to determine the total amount of phosphate cleared in every dialysis session. We would have 20 patients undergo one session of long hours dialysis, collect blood and dialysate effluent samples at regular time intervals during the course of that session and using computerised kinetic modelling determine the rate and nature of phosphate clearance. We would further examine the effect of dialysis on markers of phosphate metabolism like parathyroid hormone and Fibroblast growth factor 23 (FGF23).
REC name
North West - Greater Manchester East Research Ethics Committee
REC reference
14/NW/1441
Date of REC Opinion
26 Nov 2014
REC opinion
Favourable Opinion