Long term Quality of Life in Pancreas Transplantation
Research type
Research Study
Full title
Cross-sectional Observational Study on Long Term Quality of Life in Pancreas and Pancreas Kidney Transplant Recipients
IRAS ID
251150
Contact name
Peter J Friend
Contact email
Sponsor organisation
University of Oxford/Clinical Trial and Research Governance
Duration of Study in the UK
0 years, 5 months, 30 days
Research summary
Solid organ Pancreas Transplantation (PT) is a well-established treatment option for people with Insulin Dependent Diabetes. It is offered to a selected cohort of patients deemed fit enough for major surgery. \n\nThe most frequent form of Pancreas Transplantation is Simultaneous Pancreas Kidney Transplantation (SPK), which is offered to patients with end stage renal failure secondary to diabetes. These individuals, already in need of a kidney transplant, could potentially be eligible for a combined operation. \n\nPancreas Transplant Alone (PTA) is offered to relatively fit insulin dependent diabetic patients with preserved renal function who suffer of brittle hypoglycaemia unawareness. This is a condition that is potentially life threatening and justifies the risks of surgery.\n\nThere are other treatment options we can offer these patients: kidney transplant alone (KTA), Islet Transplantation (IT), Simoultaneous Islet and Kidney Transplantation (SIK), Traditional medical management, closed loop insulin systems.\nAll of these options can solve the most urgent clinical needs of the patients (renal failure, hypoglycaemia unawareness) at a lower risk. However, they are also associated with inferior outcomes in the long term.\n\nIn the context of tailoring the correct therapeutical approach for each individual, it is now a shared opinion amongst transplant professional that surgical risks must be weighed against clinical gain and quality of life gain. \nAfter over 50 years of Pancreas Transplantation, long term clinical outcomes have been extensively investigated, but there the long-term impact on quality of life is less known. \n\nOxford Transplant Centre is one of the highest PT volume centres worldwide with over 1000 PT transplants performed in the past two decades. For this reason this is the ideal setting to investigate long term QoL in this population.\n\nIn addition, the research team plans to investigate the impact of the current Covid-19 pandemic on anxiety and depression level in this population \n
REC name
South Central - Oxford B Research Ethics Committee
REC reference
21/SC/0145
Date of REC Opinion
18 May 2021
REC opinion
Further Information Favourable Opinion