Long Term Outcomes of Acute Kidney Injury
Research type
Research Study
Full title
Long Term Outcomes of Acute Kidney Injury - Establishing Prognosis to Design Optimal Management.
IRAS ID
154719
Contact name
Simon Sawhney
Contact email
Duration of Study in the UK
3 years, 0 months, 0 days
Research summary
Acute kidney injury(AKI) is a rapid deterioration of kidney function, typically defined by a change in blood results within a short time period. It is estimated AKI occurs in 1 in 5 hospital admissions and may lead to long term health problems or reduced survival. Research is difficult as AKI can happen unexpectedly and patients are cared for by many services. The Grampian biochemistry service covers patients receiving blood tests in the entire region regardless of where they are taken, enabling uniquely integrated potential for following up patients.
We host a large(n=70,000) cohort(GLOMMS-II) of kidney blood tests in Grampian in 2003. This data is linked to other sources for outcomes through to 2009: ISD-Scotland for morbidity data(SMR01), death registry data and the Scottish Renal Registry(SRR) for kidney outcomes.
We already have NHS R&D, University College of Ethics Review Board(CERB), Caldicott and NHS-ISD permission to use GLOMMS-II to study chronic kidney disease outcomes and validate kidney disease coding.
We now wish to use GLOMMS-II to study acute kidney injury prognosis.
1. We wish to use the same linkage sources to ISD Scotland SMR01, mortality data, and SRR, but we would like to update our linkage through to 2013(currently 2003-2009).
2. We would also like to update our biochemistry data(currently to 1999 to 2009) to 2013.
3. We wish to request additional SMR01 data on the dates of AKI, kidney and morbidity episodes, dialysis procedural codes and hospital admission data.
4. Finally, we wish to link local Grampian Intensive Care Unit data to categorise patients with AKI requiring acute renal replacement therapy(RRT) in intensive care.
We will study why some patients do better than others and whether a clinical tool for predicting long term prognosis can be generated. This would help doctors, patients and policy-makers assess future risk and healthcare requirements.
REC name
North West - Preston Research Ethics Committee
REC reference
14/NW/1371
Date of REC Opinion
13 Oct 2014
REC opinion
Favourable Opinion