Long term effects of BPD in children and adolescents v1
Research type
Research Study
Full title
An observational study of the long term effects of bronchopulmonary dysplasia on lung function in children and adolescents.
IRAS ID
307937
Contact name
Christopher Harris
Contact email
Sponsor organisation
Research & Innovation Governance Manager
Duration of Study in the UK
0 years, 4 months, 0 days
Research summary
This is an observational study to investigate the long term effects of bronchopulmonary dysplasia (BPD) on lung function in children and adolescents. BPD is chronic lung condition resulting from an imbalance between lung injury and repair that primarily affects premature newborn infants. It affects at least 13.9 per 1000 live births in infants born less that 32 weeks gestation in the UK and Ireland. [1] Severe BPD can result in poorer lung function during childhood and adulthood.
This study aims to characterise the impact of BPD on lung function in children and adolescents. We hypothesise that individuals who had BPD as neonates are more likely to have fixed obstructive airway disease that is non-responsive to pharmacological bronchodilation (e.g by salbutamol inhalers). We will recruit children and adolescents, aged between 3 and 18 years old, from King's College Hospital Paediatric Respiratory Clinic. We will have three study groups: individuals born pre-term and diagnosed with BPD as newborns; individuals born pre-term without BPD; and finally a control group of individuals born at term. We will investigate lung function using an impulse oscillometry system that uses sound waves to take passive measurement of lung mechanics during normal breathing. We will also measure body composition using non-invasive anthropometric methods. We will perform investigations in our lung function laboratory on the same day as individuals attending respiratory clinic. Lung function tests will be performed pre- and post- inhalation of a bronchodilator (salbutamol inhaler). The study will run for eight months in total.
[1]Naples R, Ramaiah S, Rankin J, et alLife-threatening bronchopulmonary dysplasia: a British Paediatric Surveillance Unit StudyArchives of Disease in Childhood - Fetal and Neonatal Edition Published Online First: 28 June 2021. doi: 10.1136/archdischild-2021-322001
REC name
London - Westminster Research Ethics Committee
REC reference
22/LO/0245
Date of REC Opinion
21 Apr 2022
REC opinion
Further Information Favourable Opinion